Displaying items by tag: Separation Science

LECO Solutions For Energy & Fuels Analysis

 

Expanding, conserving, and stretching our limited energy resources means that companies will need to be able to analyse new sources as well as validate the quality of existing supplies. LECO instruments enable energy companies to comply with increasingly stronger EPA regulations.

Microplastics: Seeing the Details with GC×GC

Microplastics: Seeing the Details with GC×GC

Microplastics are a ubiquitous presence in the world, found from Arctic snow to Antarctic ice and everywhere in between. There are trillions of microplastic particles floating on surface water, and everyone from infants to adults are presumed to be ingesting anywhere from dozens to tens of thousands of these particles every day.

VIDEO: LECO Advanced MOSH / MOAH Analyser // ON DEMAND

 Video: LECO Advance MOSH / MOAH Analyser // On Demand

Now available as an on-demand video!

Watch LECO's Advanced MOSH / MOAH Analyser in action!

Folded Flight Path®: Ten Years of High Resolution

Folded Flight Path®: Ten Years of High Resolution

The first Time-of-Flight (TOF) mass spectrometer was proposed in 1946, and the design has been refined and iterated upon every since.
With an unlimited mass range visible in each spectrum and a high spectral generation speed, the advantages of TOF mass spectrometry were immediately clear. Though the instruments improved, they did eventually hit physical limitations that restricted the resolving power. More work had to be done.

How to... Drive Faster! The Fast GC Technology Forum

THE FAST GC TECHNOLOGY FORUM

All the tricks of the trade won't be enough if your instruments can't handle the speed. LECO's Pegasus® line is designed to take full advantage of the speed of TOFMS analyses without sacrificing the sensitivity you need, and our StayClean® Ion Source means you never have to slow down to clean out your engine.

Susan Girdwood | Institute of Biological, Environmental and Rural Sciences

Aberystwyth University

"We originally expected to purchase a quadrupole instrument so buying a TOF was a little unexpected but definitely worth it as the data is far richer than what a quadrupole would have supplied. In the three years we have had the instrument running metabolomic matrixes the source has never been cleaned and the data is still superb and consistent. We love our Pegasus BT, it does a fab job of running my FAME samples including milk, yogurt, kefir, biltong and bacteria."

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David Harvey, Technical Specialist - Metabolite Profiling

CNAP | University of York

"Our metabolomics research has utilised a LECO Pegasus 4D for over 15 years. Total downtime has probably been less than 20 days for the entire 15 years. When we do have a problem or even a question about using the instrument, LECO are very swift to respond, resolve the issue and offer support and assistance usually within a day of contacting them, and quite often on the same day. The source has never been cleaned or replaced, and we still have the same detector from the original installation. Multiple papers have been produced using data produced from our LECO and I can honestly say it’s been a great asset to our team at York University."

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Prof. G. John Langley, Head of Characterisation & Analytics and Head of Mass Spectrometry | Julie M. Herniman, Specialist in Mass Spectrometry

University of Southampton

"In 2019 EPSRC funded our vision for a regional Centre of Excellence (CoE) in 2 dimensional gas chromatography and mass spectrometry. This Regional CoE, initially embracing the Universities of Bath, Portsmouth, Southampton, and Swansea, will significantly drive discovery, characterisation and quantification of new modalities, delivering a step change in capability for detection and identification of new species that cannot be separated and determined by 1D GC alone.

LECO’s Pegasus HRT 4D GC×GC-TOFMS and the benchtop BT4D GC×GC-TOFMS, both with extensive automated sample handling capability were delivered in late 2019 and early 2020. Installation of these state-of-the-art instruments was complicated by Covid-19 and lockdown 1.0. With such complex instrumentation, and application areas, effective training was key; here LECO took the initiative and provided both bespoke local and on-demand online training.

The level of service support and close collaborative relationship with LECO (applications team and account manager) has been first rate. Both systems can now be operated remotely, enabling high level users from across the South West region to access the instrumentation and allow many complex questions to be probed. Our work covers a vast array of application, e.g. petrochemical, environmental and metabolomics. The data sets are rich and complex, yet simplified by a user friendly software interface. Compared to 1D-GC, the 4D systems provide an astonishing number of additional analyte identifications, giving us deeper insight and understanding of the samples. Combining LECO’s high resolution mass spectrometry with comprehensive gas chromatography, multiple sample handling options such as SPME, Pyrolysis and TD along with full automation has created a world class laboratory of which we are all very proud."

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ONLINE WORKSHOP: Fundamentals on Comprehensive MOSH/MOAH Analysis // ON DEMAND

 LECO ONLINE WORKSHOP: Fundamentals on Comprehensive MOSH / MOAH Analysis // On Demand

The following presentations are available:

English Language
  • "Fundamentals on LC-GC Coupling" by Dr. Andreas Bruchmann | Axel Semrau GmbH & Co KG
  • "Principles and Instrumentation of GC×GC and ToF-MS" by Prof. Dr. Ir. Hans-Gerd Janssen | University of Wageningen & Unilever
  • "LC–GC×GC–ToF-MS/FID: A Powerful Platform for MOSH&MOAH Determination" by Prof. Giorgia Purcaro | University of Liège
Spanish Language
  • "Cromatografía Bidimensional Exhaustiva acoplada a Espectrometría de Masas de Tiempo de Vuelo: Características y viabilidad para el control y análisis alimentario" by Lourdes Ramos | CSIC- IQOG
  • "Contaminación MOSH / MOAH. Verificación mediante GC×GC-TOF-MS" by Silvia Losa | SGS Berlín

Our latest online presentations for MOSH / MOAH Analysis are now available as an On-Demand session. With these fundamentals you will learn all the ins and outs on the LC–GC coupling, GC×GC and Time-of-Flight MS to be able to determine MOSH and MOAH in food products.

Pegasus BT 4D | Differentiation of Regular and Barrel-Aged Maple Syrups with ChromaTOF® Tile™

LECO Solutions for MOSH/MOAH

 

Whatever your sample preparation workflow requirements are, harness the power of LECO GC×GC & TOF technology to solve the complex challenges of MOSH / MOAH Analysis.

Competence Days | Fundamentals on Comprehensive MOSH/MOAH Analysis

Webinar Fundamentals on Comprehensive MOSH-MOAH Analysis

With these fundamentals you will learn all the ins and outs on the LC–GC coupling, GC×GC and Time-of-Flight MS to able to determine MOSH and MOAH in food products. Please register for our presentations.

MDCW 2021 | Multidimensional Chromatography Workshop

MDCW 2021 | Multidimensional Chromatography Workshop

The Multidimensional Chromatography Workshop draws experts in this exciting field to share and discuss their research. The informal workshop also provides an excellent opportunity for those interested in multidimensional chromatography to learn more about this unique analytical technique. Research topics include advancements in multidimensional chromatography technology and applications of this highly selective chromatographic approach.

LECO Europe in Times of COVID-19

 LECO in Times of COVID-19

The past year with the rise of Covid-19 around the Earth has been a challenge to all of us. See how our European subsidiaries dealt with the pandemic around Europe and how our customer support and other services adapted to these new situations in the different countries. Click on the countries to see our personal experiences!

 
If you need any further information about how LECO operates during the Corona pandemic or to schedule your personal appointment with us, click on the contact button.

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The start of the years begins with the usual enthusiasm, targets set, goals to achieve and strategy to achieve them. I remember being in Dusseldorf for a managers meeting on March the 3rd. Life was still normal, and the word ’lockdown’ was only ever heard on a Friday when my children were watching Wrestling. We were able to travel, visit restaurants and have a beer without the constraints of the facemasks, social distancing and track and trace apps. Life was normal. Within a month the world changed – lockdowns, stay-at-home, work from home, stay safe.

As the LECO customers adapted to this new way of life due to COVID, so did we. Our sales force worked from home and like never before used this relatively unheard-of platform called Microsoft TEAMS to interact with customers.


“I hear the chimes of ‘TEAMS’
calling me in my sleep now.”

LECO UK Facemasks

Our service team continued to work throughout the pandemic with the new additions to their LECO uniform. LECO face masks and gloves. And of course, let’s not forget the bottles of hand sanitiser. As well as remote selling was used, remote service support came to the forefront. Both sales and service teams adapted to continue the high level of support that has become a custom with LECO.

LECO UK has been able to adapt and continued to support our customers while keeping ourselves and customers safe. Let hope moving into 2021 we can get back to some sort of previous normality. The vaccines are coming and there is a glimmer of light at the end of the tunnel but for the moment we continue with the slogan of Hands – Face – Space.

 

Michael Reaney, UK Sales Director, LECO Instruments UK Ltd.


LECO at Skolkovo Institute of Science and Technology

The first picture shows our engineer Yuri Laptev during a Pegasus 4D service visit to Skolkovo Institute of Science and Technology.

LECO at Analitika Expo Moscow

The second one was taken at the Analytika exhibition in Moscow last year.

 

Gulnara Shaidullina, Ph.D., Separation Science Sales Engineer, LECO Russia and CIS


It has for sure been a challenge even though Sweden have had less restrictions. When crossing borders to Norway, Denmark and Finland our service technicians have sometimes had to take Covid-19 tests before. We have been fortunate, no one in our team have been infected as we know of. We haven’t even been to Iceland since the start of the pandemic. Our service technicians try to go by their own cars to customers, which have meant drives up to 14 hours single way.

On the sales side it has of course been a challenge in other ways. But with ‘Teams’, online demos and Virtual Trade show our sales team have connected with our customers in the best way possible. We only attended one real trade show since the start of the pandemic – LabDays in Copenhagen – but the attendance was of course quite thin…

LabDays Copenhagen 2020

 

Lennart Schwartz, Ph.D, Sales Director Nordic Region, LECO Nordic AB


Since 14th of March of 2020, and the declaration of State of alarm in Spain, Leco Instrumentos started to work in a new different way, adapting to the new scenario of pandemic. All the employees completed a training course regarding the new risk at work and the personal protective equipment for COVID-19:

  • We all learnt about the use of face masks and the way to wash our hands
  • Some employees customised their masks… thanks to their mother’s support!
  • Remote working was the only option in most of cases.
  • Virtual meetings have come to stay.
  • The service team has been active since the first day, working in safe conditions.


Remote Service and Move LECO Spain


So far, everything was normal… But LECO Spain had to face a new challenge – to move to a new office. It was a hard task cleaning the old facilities and open boxes – a lot of boxes. And in times of COVID we had to consider to organise small groups at the office working together. Minimising risks was a priority despite of the fact that we needed to be operative in the new facility in a short time. The collaboration of the Tres Cantos-based employees was essential.

But the result made the effort worthwhile! And the Spanish LECO team is ready for 2021!

 

Leticia García, Commercial Director, Spain & Portugal


German Team Wearing Masks

From the perspective of the German Service Centre, a Corona routine has emerged throughout the past months. Customer demands increased - ever so often our service engineers are only allowed to enter labs after presenting a negative Corona test result. Of course, this requires special logistics in scheduling. In addition, there are different Corona rules the federal states of Germany and abroad, which makes planning much more difficult. But our colleagues adapt, as the pictures show, and as our colleague Manuel Lindemann describes below.

"When the pandemic really took off from March / April 2020, I first noticed a lot of uncertainty among both myself and the customers. There were many questions: What is Corona? What happens if I fall ill? How will this affect my work? Will the customers still let me enter their lab? How will LECO react? Now, almost a year later, there are still some questions left to be answered, but as humans we adapt and get used to the new circumstances – positive and negative.

in the beginning of the pandemic, I remember waiting for hours in 100m-long queues between lorry drivers and other visitors at a company and having to wait for the gatekeeper to let me pass. And there were customers who had their "special" views. From "Corona doesn't exist” to “You don't need the mask here" and "We have an internal lockdown, you can't get in" – it was all there.

After one year many questions remain unanswered, but some questions have already become obsolete. What remained as well, unfortunately, are the waiting times at customers‘ sites. Simply walking in and working on a unit is no longer possible. "Where are you from? Have you had contact with infected people? What does your Corona Warn app say? Do you have any symptoms?” ...And so on. What I've also noticed is that social interaction often gets left behind these days unfortunately – be it a casual conversation or just a gesture that disappears behind the mask. But, hopefully that is to come back soon.

But LECO protect their employees very well and always has an open ear for questions – a solution will be found together. All in all, I think we have organised ourselves very well and will probably make it through the rest of the pandemic."

 

Manuel Lindemann & Thomas Post, LECO Instrumente GmbH Deutschland


After a beginning of year full of prospects and projects, the arrival of Covid-19 took us by surprise. Italy was the first European nation to be massively attacked by the virus, the first cases recorded were in the north of the country, particularly in Lombardy, the region where the headquarters of the LECO branch in Italy are located.

To counter the spread of the virus, the entire country was placed in the "red zone" and operations were greatly reduced to adapt to the new situation.

  • The symposium of world interest on the GC×GC in Riva del Garda, as well as other local events, albeit no less important, have been cancelled
  • We did our meetings online
  • The office staff worked in smart working
  • The technical staff continued to follow their customers both remotely via the telephone and with remote interventions, and in person with the help of masks, gloves, overalls and protective goggles.


The pandemic has led us to cover our faces with masks, but it has not managed to extinguish our enthusiasm and we hope that 2021, together with the vaccine, gives us the opportunity to resume showing our smiles.

 

Rita M. Monfredini, LECO Italy S.R.L.


We’re dealing with the pandemic problem in a similar way, like the rest of the world:

  • Using, masks and gloves
  • Struggling with scheduling sales visits
  • Mostly using ‘Teams’ and mobile phones to contact with each other and with customers…
Hand Sanitiser
Brochure Delivery
 

Tomasz Stójkowski, Sales Director LECO Poland & Baltics


Europe

Online Demo Service at European Application & Technology Center Berlin

Since February 2020 we provide an Online Demo Service at our European Application & Technology Center in Berlin, giving customers an insight into our LECO products and laboratory processes conveniently from their desks and without the need to travel. For our Online Demo Service, a good preparation is required to meet our's and our customers’ high standards.

Preparation

  1. The sales enigneer requests instrument, possible date, and time at the EATC
  2. After feedback, the date and time is clarified with the customer
  3. After completion of our internal Event Request Form to collect all needed information about the customer, instrument, date and time the EATC blocks the date for the customer
  4. The team at EATC provides an online meeting link accordingly and invites the sales engineer to this meeting
  5. The sales engineer then provides the invitation with this link to their customer and if needed other colleagues who will participate.


Demo Day

  1. Customer and sales engineer login to the online meeting which will be started by the EATC team.
  2. The camera at EATC is usually placed in front of the desired instrument, when the meeting starts.
  3. The sales engineer starts with an introduction of themselves and the EATC team in local language.
  4. This is followed by some introductory words to outline the demo – also in local language
  5. The EATC team can do measurements of standards, explain the analysis, and point and zoom the camera wherever needed to get the best possible instrument and software overview.
  6. It is also possible to measure customer samples, if they are provided some days in advance to the online demo.
     

Online Demo Service at EATC Berlin


Get in touch with us to arrange an individual online appointment for you!


Visit our LECO Virtual Trade Show

Due to the Corona pandemic, numerous trade shows and events are being cancelled or postponed where we would have liked to welcome or customers as a guest. To give you the opportunity to stay in touch with LECO, we have organised our LECO Virtual Trade Show. Our specialists invite you to get to know our solutions for various application fields and markets in a personal meeting.

Visit our registration website and book your free ticket today. Your local sales partner will schedule a meeting and guide you through our exhibition and introduce you to our solutions for your lab.

GET YOUR FREE TICKET

Get your free ticket today!

The Difference between Frankincense and Myrrh

The Difference between Frankincense and Myrrh

It's that time of year again, when holiday songs play 24/7 on the radio and people start wondering what, exactly, frankincense and myrrh are and why they make good gifts. LECO placed these two oils in a Pegasus BT 4D to see the difference.

Frankincense (from the boswellia tree) and myrrh (from the commiphora tree) are both resins which are commonly used as perfumes and incense and have been for thousands of years. Essential oils extracted from these resins can be analyzed using gas chromatography, which is precisely what the scientists at LECO did.

By extending the analysis to a second dimension using the GC×GC analysis of the Pegasus BT 4D, even more information can be gleaned from the samples extracted from these substances. GC×GC analysis also inherently produces structured chromatograms where chemically similar analytes tend to elute in ordered bands through the GC×GC separation space. This provides context for identification and allows for rapid visual characterization of the compound classes.

 

Chromatogram of Frankincense and Myrrh

 

For a more detailed breakdown of the analysis of these oils and how the GC×GC separation provides a huge advantage in the characterisation and comparison of these samples, check out our latest APPLICATION NOTE.

ON-DEMAND | GC×GC-HR-TOFMS for untargeted screening of Breathomics

Watch the LECO’s webinar in cooperation with The Analytical Scientist now available for on-demand viewing. The webinar features "GC×GC-HR-TOFMS for untargeted screening of Breathomics" by Pierre-Hugues Stefanuto, Lead Scientist at University of Liège

Learn your new PEGASUS® BT on your schedule

Learn your new PEGASUS® BT on your schedule

Your Pegasus® BT is a powerful instrument, but if you're unsure how to use some of its features, you aren't able to get the full benefit from your investment. LECO is rolling out LECOLearn, an online, on-demand training site to help you maximise your laboratory.

LECO Solutions for Metabolomics

 

Metabolomics presents challenges for both the analytical methods used and the data reduction required to interpret the results. No single analytical technique can be used for complete characterisation of the metabolome, and no metabolome has been completely characterised. However, GC-MS provides an established method to analyse the primary metabolome, whereas LC investigates the secondary and tertiary metabolites.

"The Ultimate Untargeted Technique" – LECO in colaboration with the Analytical Scientist

The rise of omics has been a hot topic in our group for the past few years – in part because our own expertise aligns somewhat with the needs of these fields. Metabolomics is then particularly challenging for the separation science community, demanding the application of high-end iterations of various techniques, including LC, GC, MS, and NMR. In fact, when it comes to metabolomics, most analytical tools have a “seat at the technique table” – after all, multimodality is the only way to make sense of such high sample complexity.

An Article by Pierre-Hugues Stefanuto, Delphine Zanella, and Jean-François Focant

See what's in your food // Food Safety e-seminars on-demand

See What's in Your Food

How efficient is your workflow when it comes to food samples? Are you sure you're seeing everything your sample has to offer? Learn how LECO has been expanding what is possible when it comes to food safety analyses with this free series of webinars.

Winners of the LECO Analytical Applications Poster Competition // LA²PC 2020/2021

Winners of the LECO Analytical Applications Poster Competition 2020

LECO hosted the LA2PC // Analytical Applications Poster Competition with the aim of improving our understanding and knowledge of LECO users’ work and research. This was a great opportunity to learn more from our users and introduce their work with LECO instruments to a wider base. LECO is proud that so many excellent posters were submitted. All entries are displayed in our poster gallery.

LECO & Helmholtz Institut München in colaboration with Separation Science

Dr. Ralf Löscher, Vice President of LECO Europe, talks to Thomas Gröger and Dr. Jürgen Schnelle-Kreis from the Helmholtz Zentrum München – the German Research Center for Environmental Health to learn about the impact of aerosols on our everyday life and health and gain some background information on their work.

READ FULL INTERVIEW

New Pegasus® BT 4D Nofer Institute of Occupational Medicine in Łódź

New Pegasus® BT 4D Nofer Institute of Occupational Medicine in Łódź

We are proud to announce the successful delivery and installation of a unique apparatus set at our unique customer. NOFER INSTITUTE OF OCCUPATIONAL MEDICINE in Łódź, which includes the BIOLOGICAL MONITORING AND ENVIRONMENT DEPARTMENT, headed by Prof. Dr. hab. n. med. Wojciech Wąsowicz is a thriving and opinion-forming center, participating in many national and international programs.

See What's in Your Food // Food Safety Webinar Series with LECO

See What's in Your Food

How efficient is your workflow when it comes to food samples? Are you sure you're seeing everything your sample has to offer? Learn how LECO has been expanding what is possible when it comes to food safety analyses with this free series of webinars.

All our webinars will be approximately 30 minutes long with a Q&A session at the ends. Register for any or all that interest you!

Register for our e-Seminar on SepScience

Or visit our New Virtual Trade Showheader blogpost eseminar 1440x390px

Please join us for two upcoming eSeminars on SepScience.com. We present how state of the art LECO GC-TOF-MS and GC×GC-TOF-MS technologies can dramatically enhance your applications for Food Analysis (9th June) and Environmental (11th June).

Click to register now!

"The detection of honey bee diseases through monitoring shifts in volatile profiles" by Maggie Gill – Keele University, UK

header blogpost eseminar 1440x390px

Today, 20th May, is UN World Honey Bee Day. The honey bee is an important pollinator species that contributes an estimated $15 billion a year to the US economy through crop pollination and £690 million to the UK economy. Honey bees are also important wild pollinators, and play a key role in maintaining biodiversity and ecosystem services in many ecosystems.

"Evaluating Oxidized Base Oils by Flow Modulated GC×GC-TOFMS" by Paul Harvath

At LECO’S GC×GC Workshop & Symposium (filmed at the LECO European Application and Training Centre, Berlin, Germany) Paul Harvath gave a talk entitled "Evaluation of Oxidized Base Oils by Flow Modulated Two-Dimensional Gas Chromatography – Time of Flight Mass Spectrometry". In his talk he gave an insight about the history and future of engine oils for cars, and how the lubricants changed over the times.

Dr. Nunzia Iaccarino, Ph.D.

Department of Pharmacy, University of Naples Federico II

"I have been using a GC-TOFMS Pegasus BT since January 2018 for Metabolomics projects. I have mainly analysed murine tissues extracts, and, I'm very happy about its robustness and high sensitivity."

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Raphaël Lugan, Enseignant Chercheur

UMR QualiSud, University of Avignon, France

"I use a LECO mass spectrometer for plant metabolomics ; it is an efficient machine with a very low detection limit and the Chromatof deconvolution algorithm allows to find hundreds of compounds in complex extracts."

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Jaromír Hradecký, Ph.D.

Faculty of Forestry and Wood Sciences, Czech University of Life Sciences Prague, Czech Republic

"I have been working with LECO instruments for approx. ten years. I worked with the PEGASUS® 4D, TruTOF, GC-HRT and, for few days in Berlin, with the Pegasus BT and BT 4D – I really enjoyed that. There are several reasons why I like working with the devices and why I would not consider using other GC-MS insturments.

  • LECO instruments are reliable and robust with well working peak find and mass spectral deconvolution algorithms.
  • In principle, LECO instruments are allowing both target and non target analysis which can be performed in one run, with nice sensitivity.
  • Data processing is easy and everything is done in one SW – no need to use complicated combinations of SWs.
  • LECO has an excellent customers support"
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Dr. Martyn Ward, Experimental Officer

Wolfson Atmospheric Chemistry Laboratories, University of York

"Following years of service from the old LECO PEGASUS® 4D TOF GC-MS, we upgraded to a new LECO Pegasus BT4D TOF GC-MS. The decision was made due to the exceptional separating power afforded by thecryogenic modulation and the durability of the LECO StayClean® sourcetechnology which has been carried into the updated system. The combination of the two open up a wide variety of analyses to us whichenable use of this instrument in many aspects of our research."

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Dr. Katie Read, Coordinator of the Cape Verde Atmospheric Observatory (CVAO)

National Centre for AtmosphericScience (NCAS), University of York

"We send instruments into the harshest of environments and run very demandingsamples on them. Bearing this in mind, our decision to upgrade the GC-MS at our remote Cape-Verde site to the new LECO PEGASUS® BT was driven by the promise of the StayClean® source. This minimizes down time and eliminates operations which are difficult to carry out when working with remote systems. The increased sensitivity of theinstrument enables us to take smaller sample volumes which again assists with easing the burden placedon the analytical machine. Finally! the upgrade from quadrupole to time of flight mass spec will enable us to keep historical datasets which can be interrogated for any compounds which prove interesting in the future."

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Dr. Mara Knapp, Laboratory Business Development Manager

Department of Civil Engineering University of Strathclyde

"In 2013, I became responsible for overseeing the department’s analytical suitewhich included a LECO PEGASUS® 4D GC×GC TOF MS as our flagshipinstrument. I had no experience in gas chromatography and found even a standard GCMS daunting. Over the past years, I received extensive support from LECO. Especially withsupport from LECO UK the instrument is still running strong a decade after purchase. I anticipate it will go for another decade and then some."

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John Quick, Principal Scientist

ALS Enviromental, United Kingdom

"I believe this technology and methodology will profoundly change water analysis realising major benefi ts for both laboratories and their customers."

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Silvia Aguiló Losa

SGS Institut Fresenius GmbH Berlin, Germany

"We at SGS MOSH/MOAH group are using the GC × GC-TOFMS from LECO to separate the highly complex fractions of MOSH/MOAH contaminates in food. When you want to identify special patterns of contamination species amongst other analytics (e. g carotenoids) you need a high separation power in combination with a fast screening MS. This is provided by the LECO TOF. Actually we have a new project together with LECO and another company to quantify MOSH/MOAH fractions. The complexity of the instrumentation is high, but with the support of the application team from LECO we reach our goals."

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Pedro Antunes, Senior Tech. & Co-Ordinator Organic Chemistry

Environment Reference Lab, APA – Agência Portuguesa do Ambiente

"Initially we had some fears about whether the option of the time of flight detector would be the best for our laboratory, since we have no other system of this kind installed. However, at the end of 6 months of operation with the GC-TOFMS system, it was widely recognized internally that we made the right choice. An easy-to-operate system with high sensitivity, reproducibility and severalanalysis options for a large universe of analytes, and in the most varied matrices increases the versatility of laboratory operation as well as the possibility of responding to the most demanding customer requests."

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Dr. Alexey Shavarda

Centre for Molecular and Cell Technologies, Saint Petersburg State University Research Park

  • Analytical Phytochemistry Laboratory // Komarov Botanical Institute
  • Department of Plant Physiology and Biochemistry // Saint Petersburg State University
  • Department of Plant Biochemistry and Molecular Biology // Vavilov Research Institute of Plant Industry

"Our virtual metabolomics research center has six GC-MS instruments, and the LECO PEGASUS® 4D is the crown jewel of our science park. The results of GC-MS profiling performed using GC×GC technologies has madea strong impression on users and has seriously improved the quality of ourpublications. The fast-scanning capabilities of the TOF-analyzer effectively augment the dataobtained on the ordinary quadrupole, especially when working with the most complexmatrices which are most often the subject of metabolomics analysis. The reliability of the device is especially deserving of praise. The equipment can withstand a very demanding load with constant, round-the-clock operation."

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Dott. Marcello Manfredi

Università degli Studi del Piemonte Orientale, Italy

"With the Pegasus BT 4D performing untargeted analysis today is very easy, thanks to the high sensitivity of the instrument, we are able to mine and analyze any type of sample! A combination of very good sensitivity, quality to price ratio and high flexibility make the Pegasus BT 4D system perfect for analysis of every sample"

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Prof. Antonio Randazzon

University of Naples, Italy

"Pegasus BT is the perfect choice for identifying well-known metabolites at low concentration level in our sample, and also discovering new compounds. The most surprising advantage of the BT system is the ion source robustness! We usually work with dirty and complex samples, but we have never observed drop of sensitivity during our analyses.This reduces the time and cost of our analyses!"

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Alex Dickens, Co-Ordinator

TURKU Metabolomics Facility, Finland

"We use the LECO Pegasus BT instrument for the quantification of small polar metabolites. We developed a hybrid method where we quantitate 51 metabolites with standard curves and screen for any other small polar metabolites in a wide range of biological samples. This assay has a great dynamic range thanks to the sensitivity of the BT. The StayClean® ion source allows us to run hundreds of samples in a batch and be confi dent that the ion source will remain clean even with dirty samples such as plasma."

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Ph.D. Jan Rezek, Ing.

Czech Academy of Science, Tschechische Republik

"Compared to GC equipped with a single column, the Pegasus 4D enabled me to separate unbelievable number of analytes! Tens of thousands of separated peaks in one run was not an exception. But where the separation was not perfect, ChromaTOF software and its deconvolution algorithm did the job. Such excellent ‘separating power’ helped me discover new types of plant PCB metabolites."

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Prof. Ralf Zimmermann

Helmholtz Zentrum München (HMGU) Department “Comprehensive Molecular Analytics“, Germany

"This combination of ultrahigh chromatographic separation with high mass resolution might be still unique for a commercial available end user system."

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SeparationScience featuring LECO Food Testing Applications e-Book

Our new eBook summarises a large part of LECO’s application work in the field of food testing. In addition to the Application Compendium, the eBook includes an introduction to GC×GC- and TOFMS-technology, followed by an overview of the different hardware and software solutions that were used for the food testing applications. A bibliography with additional references can be found in the appendix.

The eBook is downloadable at SeparationScience now.
Download the eBook here… 

Visit our Berlin Lab – Online

NEW Online Demo Service at our European Application and Technology Center in Berlin

We can now present our instruments and application solutions to you ONLINE, enabling you to gain insight into how LECO products could enhance your laboratory processes and results!

Visit us conveniently from your desk and without the need to travel. Our new ONLINE DEMO SERVICE allows you see product introductions and receive tips and tricks from our experts.

Would you like to know how we can help your sample analyses?
Just let us know and we can arrange a demo!

Contact your local sales team for an individual online appointment.

 

Cannabis Questions? More Answers in one Injection

As laws and regulations change, cannabis and all it’s related chemical compounds of interest are showing up in a wide variety of consumer products. LECO instruments, that combine powerful Time-of-Flight Mass Spectrometry (TOF-MS) and Comprehensive Two Dimensional Gas Chromatography (GC×GC) technologies, can make your analyses more efficient. Find out here, how to save time and money by quantifying and identifying both the terpene and cannabinoids in just one injection. The same injection can even reveal the presence of pesticides and more!

How can we do this? Using GC×GC drastically increases analyte separation, which together with high quality full mass range spectra obtained by TOF-MS, enables powerful deconvolution analyte finding using ChromaTOF.

Do you want to learn more about "Determining Terpene Profiles of Cannabis Strains", then watch the presentation of Joe Binkley, Director - Separation Science Applications.

WATCH THE VIDEO HERE…

"Selectivity: When, Where, and How to Use It!" by Diane Turner at LECO’S GC×GC Workshop & Symposium

At LECO’S GC×GC Workshop & Symposium, Dr. Diane Turner gave a talk about "Selectivity: Wann, wo und wie man sie nutzt“ The talk covers techniques for sample analysis, selectivity in choosing the right technical setup (column choice, inlet parameters etc.), and also data analysis optimisation.

“GC×GC Separation” by Alan Griffiths at London Metabolomics Meeting of the RSC

Meeting of the London Metabolomics Network and South East Region Analytical Division of the Royal Society of Chemistry at Burlington House, London

Alan Griffiths speaks about the top of the range technique for GC×GC Separation provided by LECO. The video has been recorded at the meeting of the London Metabolomics Network and South East Region Analytical Division of the Royal Society of Chemistry at Burlington House, London. The video will be uploaded to SepScience.com for our recent PEGASUS® campaign.

WATCH THE VIDEO HERE…

Of Fireworks and Tourism: GC×GC-HRMS Analysis of Summer Impacts on Lake Michigan Water Quality

Fireworks are a staple of America’s Independence Day celebrations. It is estimated that 16,000 fireworks displays are held in the United States each year and American consumers will spend more than $1 billion in firework sales to mark the holiday! Beyond a big bang and bright lights, how do these fireworks affect the environmental world around them? LECO’s world headquarters are located in Saint Joseph, Michigan, a beach town on Lake Michigan where fireworks are a prominent backdrop to the 4th of July celebration. Last summer, our applications lab thought it would be a worthwhile and interesting experiment to test the water surrounding the firework launch spot to explore if there were any short-term environmental impacts. The influx of tourists to the Lake Michigan beaches during the holiday is sure to contribute chemicals from personal care products (sunscreen and insect repellent) to the water as well. Evaluating these potential contaminants surrounding the July 4th holiday was the objective of this study.

The analysis was conducted by taking water samples from three different places along the shoreline; the fireworks launch location off the pier, as well as two local beaches close to the launch site. This was done on July 2nd as well as on July 4th (an hour after the fireworks show) to provide an accurate measurement. LECO’s Pegasus HRT+ 4D system was used to analyse the water samples, which offers comprehensive two-dimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS). GC×GC-HRTOFMS proved a powerful tool for exploration as it provided a full non-targeted analysis of the water samples before and after the fireworks show, clearly demonstrating the chemical differences between the two. GC×GC-HRTOFMS was also able to pinpoint contributions to the environmental pollution that occurred as a result of these pyrotechnic displays and the increased human traffic near the water sampling sites.

So what happened to the water quality of Lake Michigan from the increased tourism and fireworks? The results may surprise you…

Read the poster here to find out.

Mass spectrometry and the history of GC-TOFMS by Alan Griffiths

 Non-targeted analysis, data science and innovation have synchronised to underpin the next generation of separation science analysis in mass spectrometry. LECO UK’s separations science product specialist Alan Griffiths explains.

“Ideas often spark one another, and chain reactions occur. As with chemical reactions, ideas can remain contained in relatively small areas before gradually spreading outward. California’s Silicon Valley is a focal point for technology. For mass spectrometry (MS), the UK’s city of Manchester is a focal point. Manchester is where the first commercial mass spectrometer built outside of the US was produced…“

Read the full article here…

Chemistry World // Issue 12/2019 // Article by Alan Griffiths

e-Food Lab International // Interview with Ralf Löscher

Ralf Löscher speaks about the latest technologies, as well as many years experience LECO has in the field of TOFMS instrumentation. The special focus of this interview refers to the food industry and the special benefits LECO offers to this market.

“In the field of chromatographic separation science technology, LECO offers GC coupled to time-of-flight (TOF) mass spectrometry (MS). This includes one-dimensional as well as two-dimensional chromatography (GC×GC), which increases chromatographic resolution and sensitivity. In addition, our latest technology is competitively priced in relation to triple quadrupole alternatives. Furthermore, GC-TOF-MS technology is basically unbeatable for the analysis of residues in complex matrices such as teas, spices, oily products, but also baby food.“

READ MORE…

eFoodLab // Issue 02/2019 // Interview with Ralf Löscher

 

Winners of our Scientific Poster Competition 2019

Congratulations to the winner of LECO UK’s first poster competition Rachel Hand of De Montfort University / The Open University and also to our runner-up Sonia García Alcega of The Open University.

ASMS in Review: Frank Dorman, Penn State

Frank Dorman, an Associate Professor of Biochemistry and Molecular Biology at Penn State University, spoke at our ASMS breakfast seminar about his experience using our Pegasus BT 4D benchtop GC×GC-TOFMS to analyze environmental contamination in the Susquehanna river.

New Pegasus® GC-HRT+ 4D for the University of Southampton

LECO’s PEGASUS® GC-HRT+ 4D will be the newest addition to the University of Southampton’s School of Chemistry, offering unique capabilities to UK researchers. Read what Professor John Langley has to say about the new mass spectrometer. “Highly advanced Southampton spectrometer to spearhead chemical research across southern region. Researchers across the south of England will analyse novel and strategically important chemistries through a new mass spectrometer at the University of Southampton.“

LS3UK // LECO Separation Science Symposium UK 2019

Interesting talks, excellent speakers, great conversations and discussions, stunning food and an amazing venue all lead to a great LS3UK in Manchester on 29 – 30 October.

LECO in colaboration with Separation Science

Following the recent 15th Annual Conference of the Metabolomic Society in the Hague, Dr Ralf Löscher, Vice President of LECO Europe, took some time to answer some questions concerning LECO's role as a leader in GC-MS metabolomics. The full interview can be downloaded below.

READ FULL ARTICLE

Workshop: Metabolomics

LECO invites you to a diverse Metabolomics Analysis event at the EATC in Berlin. Expert speakers will present how the use of LECO GC-TOF-MS and GC×GC-TOF-MS enhances their latest target and untargeted metabolomics analysis applications in various fields such as Human disease, foodomics and plant biomarkers. These lectures will be supplemented with a laboratory session showcasing the latest LECO instrumentation and software. The participation is free of charge, including a special evening event on 27th November!

REGISTER NOW

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