Whatever your sample preparation workflow requirements are, harness the power of LECO GCxGC & TOF technology to solve the complex challenges of MOSH/MOAH Analysis.
With these fundamentals you will learn all the ins and outs on the LC–GC coupling, GC×GC and Time-of-Flight MS to able to determine MOSH and MOAH in food products. Please register for our presentations.
The Multidimensional Chromatography Workshop draws experts in this exciting field to share and discuss their research. The informal workshop also provides an excellent opportunity for those interested in multidimensional chromatography to learn more about this unique analytical technique. Research topics include advancements in multidimensional chromatography technology and applications of this highly selective chromatographic approach.
The past year with the rise of Covid-19 around the Earth has been a challenge to all of us. See how our European subsidiaries dealt with the pandemic around Europe and how our customer support and other services adapted to these new situations in the different countries. Click on the countries to see our personal experiences!
If you need any further information about how LECO operates during the Corona pandemic or to schedule your personal appointment with us, click on the contact button.
The start of the years begins with the usual enthusiasm, targets set, goals to achieve and strategy to achieve them. I remember being in Dusseldorf for a managers meeting on March the 3rd. Life was still normal, and the word ’lockdown’ was only ever heard on a Friday when my children were watching Wrestling. We were able to travel, visit restaurants and have a beer without the constraints of the facemasks, social distancing and track and trace apps. Life was normal. Within a month the world changed – lockdowns, stay-at-home, work from home, stay safe.
As the LECO customers adapted to this new way of life due to COVID, so did we. Our sales force worked from home and like never before used this relatively unheard-of platform called Microsoft TEAMS to interact with customers.
Our service team continued to work throughout the pandemic with the new additions to their LECO uniform. LECO face masks and gloves. And of course, let’s not forget the bottles of hand sanitiser. As well as remote selling was used, remote service support came to the forefront. Both sales and service teams adapted to continue the high level of support that has become a custom with LECO.
LECO UK has been able to adapt and continued to support our customers while keeping ourselves and customers safe. Let hope moving into 2021 we can get back to some sort of previous normality. The vaccines are coming and there is a glimmer of light at the end of the tunnel but for the moment we continue with the slogan of Hands – Face – Space.
Michael Reaney, UK Sales Director, LECO Instruments UK Ltd.
The first picture shows our engineer Yuri Laptev during a Pegasus 4D service visit to Skolkovo Institute of Science and Technology.
The second one was taken at the Analytika exhibition in Moscow last year.
Gulnara Shaidullina, Ph.D., Separation Science Sales Engineer, LECO Russia and CIS
It has for sure been a challenge even though Sweden have had less restrictions. When crossing borders to Norway, Denmark and Finland our service technicians have sometimes had to take Covid-19 tests before. We have been fortunate, no one in our team have been infected as we know of. We haven’t even been to Iceland since the start of the pandemic. Our service technicians try to go by their own cars to customers, which have meant drives up to 14 hours single way.
On the sales side it has of course been a challenge in other ways. But with ‘Teams’, online demos and Virtual Trade show our sales team have connected with our customers in the best way possible. We only attended one real trade show since the start of the pandemic – LabDays in Copenhagen – but the attendance was of course quite thin…
Lennart Schwartz, Ph.D, Sales Director Nordic Region, LECO Nordic AB
Since 14th of March of 2020, and the declaration of State of alarm in Spain, Leco Instrumentos started to work in a new different way, adapting to the new scenario of pandemic. All the employees completed a training course regarding the new risk at work and the personal protective equipment for COVID-19:
So far, everything was normal… But LECO Spain had to face a new challenge – to move to a new office. It was a hard task cleaning the old facilities and open boxes – a lot of boxes. And in times of COVID we had to consider to organise small groups at the office working together. Minimising risks was a priority despite of the fact that we needed to be operative in the new facility in a short time. The collaboration of the Tres Cantos-based employees was essential.
But the result made the effort worthwhile! And the Spanish LECO team is ready for 2021!
Leticia García, Commercial Director, Spain & Portugal
From the perspective of the German Service Centre, a Corona routine has emerged throughout the past months. Customer demands increased - ever so often our service engineers are only allowed to enter labs after presenting a negative Corona test result. Of course, this requires special logistics in scheduling. In addition, there are different Corona rules the federal states of Germany and abroad, which makes planning much more difficult. But our colleagues adapt, as the pictures show, and as our colleague Manuel Lindemann describes below.
"When the pandemic really took off from March / April 2020, I first noticed a lot of uncertainty among both myself and the customers. There were many questions: What is Corona? What happens if I fall ill? How will this affect my work? Will the customers still let me enter their lab? How will LECO react? Now, almost a year later, there are still some questions left to be answered, but as humans we adapt and get used to the new circumstances – positive and negative.
in the beginning of the pandemic, I remember waiting for hours in 100m-long queues between lorry drivers and other visitors at a company and having to wait for the gatekeeper to let me pass. And there were customers who had their "special" views. From "Corona doesn't exist” to “You don't need the mask here" and "We have an internal lockdown, you can't get in" – it was all there.
After one year many questions remain unanswered, but some questions have already become obsolete. What remained as well, unfortunately, are the waiting times at customers‘ sites. Simply walking in and working on a unit is no longer possible. "Where are you from? Have you had contact with infected people? What does your Corona Warn app say? Do you have any symptoms?” ...And so on. What I've also noticed is that social interaction often gets left behind these days unfortunately – be it a casual conversation or just a gesture that disappears behind the mask. But, hopefully that is to come back soon.
But LECO protect their employees very well and always has an open ear for questions – a solution will be found together. All in all, I think we have organised ourselves very well and will probably make it through the rest of the pandemic."
Manuel Lindemann & Thomas Post, LECO Instrumente GmbH Deutschland
After a beginning of year full of prospects and projects, the arrival of Covid-19 took us by surprise. Italy was the first European nation to be massively attacked by the virus, the first cases recorded were in the north of the country, particularly in Lombardy, the region where the headquarters of the LECO branch in Italy are located.
To counter the spread of the virus, the entire country was placed in the "red zone" and operations were greatly reduced to adapt to the new situation.
The pandemic has led us to cover our faces with masks, but it has not managed to extinguish our enthusiasm and we hope that 2021, together with the vaccine, gives us the opportunity to resume showing our smiles.
Rita M. Monfredini, LECO Italy S.R.L.
We’re dealing with the pandemic problem in a similar way, like the rest of the world:
Tomasz Stójkowski, Sales Director LECO Poland & Baltics
Since February 2020 we provide an Online Demo Service at our European Application & Technology Center in Berlin, giving customers an insight into our LECO products and laboratory processes conveniently from their desks and without the need to travel. For our Online Demo Service, a good preparation is required to meet our's and our customers’ high standards.
Get in touch with us to arrange an individual online appointment for you!
Due to the Corona pandemic, numerous trade shows and events are being cancelled or postponed where we would have liked to welcome or customers as a guest. To give you the opportunity to stay in touch with LECO, we have organised our LECO Virtual Trade Show. Our specialists invite you to get to know our solutions for various application fields and markets in a personal meeting.
Visit our registration website and book your free ticket today. Your local sales partner will schedule a meeting and guide you through our exhibition and introduce you to our solutions for your lab.
GET YOUR FREE TICKET
It's that time of year again, when holiday songs play 24/7 on the radio and people start wondering what, exactly, frankincense and myrrh are and why they make good gifts. LECO placed these two oils in a Pegasus BT 4D to see the difference.
Frankincense (from the boswellia tree) and myrrh (from the commiphora tree) are both resins which are commonly used as perfumes and incense and have been for thousands of years. Essential oils extracted from these resins can be analyzed using gas chromatography, which is precisely what the scientists at LECO did.
By extending the analysis to a second dimension using the GC×GC analysis of the Pegasus BT 4D, even more information can be gleaned from the samples extracted from these substances. GC×GC analysis also inherently produces structured chromatograms where chemically similar analytes tend to elute in ordered bands through the GC×GC separation space. This provides context for identification and allows for rapid visual characterization of the compound classes.
For a more detailed breakdown of the analysis of these oils and how the GC×GC separation provides a huge advantage in the characterisation and comparison of these samples, check out our latest APPLICATION NOTE.
Whatever your sample preparation workflow requirements are, harness the power of LECO GCxGC & TOF technology to solve the complex challenges of MOSH/MOAH Analysis.
Watch the LECO’s webinar in cooperation with The Analytical Scientist now available for on-demand viewing. The webinar features "GC×GC-HR-TOFMS for untargeted screening of Breathomics" by Pierre-Hugues Stefanuto, Lead Scientist at University of Liège
Your Pegasus® BT is a powerful instrument, but if you're unsure how to use some of its features, you aren't able to get the full benefit from your investment. LECO is rolling out LECOLearn, an online, on-demand training site to help you maximise your laboratory.
Metabolomics presents challenges for both the analytical methods used and the data reduction required to interpret the results. No single analytical technique can be used for complete characterisation of the metabolome, and no metabolome has been completely characterised. However, GC-MS provides an established method to analyse the primary metabolome, whereas LC investigates the secondary and tertiary metabolites.
The rise of omics has been a hot topic in our group for the past few years – in part because our own expertise aligns somewhat with the needs of these fields. Metabolomics is then particularly challenging for the separation science community, demanding the application of high-end iterations of various techniques, including LC, GC, MS, and NMR. In fact, when it comes to metabolomics, most analytical tools have a “seat at the technique table” – after all, multimodality is the only way to make sense of such high sample complexity.
An Article by Pierre-Hugues Stefanuto, Delphine Zanella, and Jean-François Focant
LECO hosted the LA2PC // Analytical Applications Poster Competition with the aim of improving our understanding and knowledge of LECO users’ work and research. This was a great opportunity to learn more from our users and introduce their work with LECO instruments to a wider base. LECO is proud that so many excellent posters were submitted. All entries are displayed in our poster gallery.
Dr. Ralf Löscher, Vice President of LECO Europe, talks to Thomas Gröger and Dr. Jürgen Schnelle-Kreis from the Helmholtz Zentrum München – the German Research Center for Environmental Health to learn about the impact of aerosols on our everyday life and health and gain some background information on their work.
We are proud to announce the successful delivery and installation of a unique apparatus set at our unique customer. NOFER INSTITUTE OF OCCUPATIONAL MEDICINE in Łódź, which includes the BIOLOGICAL MONITORING AND ENVIRONMENT DEPARTMENT, headed by Prof. Dr. hab. n. med. Wojciech Wąsowicz is a thriving and opinion-forming center, participating in many national and international programs.
How efficient is your workflow when it comes to food samples? Are you sure you're seeing everything your sample has to offer? Learn how LECO has been expanding what is possible when it comes to food safety analyses with this free series of webinars.
All our webinars will be approximately 30 minutes long with a Q&A session at the ends. Register for any or all that interest you!
Please join us for two upcoming eSeminars on SepScience.com. We present how state of the art LECO GC-TOF-MS and GC×GC-TOF-MS technologies can dramatically enhance your applications for Food Analysis (9th June) and Environmental (11th June).
Click to register now!
Today, 20th May, is UN World Honey Bee Day. The honey bee is an important pollinator species that contributes an estimated $15 billion a year to the US economy through crop pollination and £690 million to the UK economy. Honey bees are also important wild pollinators, and play a key role in maintaining biodiversity and ecosystem services in many ecosystems.
At LECO’S GC×GC Workshop & Symposium (filmed at the LECO European Application and Training Centre, Berlin, Germany) Paul Harvath gave a talk entitled "Evaluation of Oxidized Base Oils by Flow Modulated Two-Dimensional Gas Chromatography – Time of Flight Mass Spectrometry". In his talk he gave an insight about the history and future of engine oils for cars, and how the lubricants changed over the times.
"I have been using a GC-TOFMS Pegasus BT since January 2018 for Metabolomics projects. I have mainly analysed murine tissues extracts, and, I'm very happy about its robustness and high sensitivity."
"I use a LECO mass spectrometer for plant metabolomics ; it is an efficient machine with a very low detection limit and the Chromatof deconvolution algorithm allows to find hundreds of compounds in complex extracts."
"I have been working with LECO instruments for approx. ten years. I worked with the PEGASUS® 4D, TruTOF, GC-HRT and, for few days in Berlin, with the Pegasus BT and BT 4D – I really enjoyed that. There are several reasons why I like working with the devices and why I would not consider using other GC-MS insturments.
"Following years of service from the old LECO PEGASUS® 4D TOF GC-MS, we upgraded to a new LECO Pegasus BT4D TOF GC-MS. The decision was made due to the exceptional separating power afforded by thecryogenic modulation and the durability of the LECO StayClean® sourcetechnology which has been carried into the updated system. The combination of the two open up a wide variety of analyses to us whichenable use of this instrument in many aspects of our research."
"We send instruments into the harshest of environments and run very demandingsamples on them. Bearing this in mind, our decision to upgrade the GC-MS at our remote Cape-Verde site to the new LECO PEGASUS® BT was driven by the promise of the StayClean® source. This minimizes down time and eliminates operations which are difficult to carry out when working with remote systems. The increased sensitivity of theinstrument enables us to take smaller sample volumes which again assists with easing the burden placedon the analytical machine. Finally! the upgrade from quadrupole to time of flight mass spec will enable us to keep historical datasets which can be interrogated for any compounds which prove interesting in the future."
"In 2013, I became responsible for overseeing the department’s analytical suitewhich included a LECO PEGASUS® 4D GC×GC TOF MS as our flagshipinstrument. I had no experience in gas chromatography and found even a standard GCMS daunting. Over the past years, I received extensive support from LECO. Especially withsupport from LECO UK the instrument is still running strong a decade after purchase. I anticipate it will go for another decade and then some."
"I believe this technology and methodology will profoundly change water analysis realising major beneﬁ ts for both laboratories and their customers."
"We at SGS MOSH/MOAH group are using the GC × GC-TOFMS from LECO to separate the highly complex fractions of MOSH/MOAH contaminates in food. When you want to identify special patterns of contamination species amongst other analytics (e. g carotenoids) you need a high separation power in combination with a fast screening MS. This is provided by the LECO TOF. Actually we have a new project together with LECO and another company to quantify MOSH/MOAH fractions. The complexity of the instrumentation is high, but with the support of the application team from LECO we reach our goals."
"Initially we had some fears about whether the option of the time of flight detector would be the best for our laboratory, since we have no other system of this kind installed. However, at the end of 6 months of operation with the GC-TOFMS system, it was widely recognized internally that we made the right choice. An easy-to-operate system with high sensitivity, reproducibility and severalanalysis options for a large universe of analytes, and in the most varied matrices increases the versatility of laboratory operation as well as the possibility of responding to the most demanding customer requests."
"Our virtual metabolomics research center has six GC-MS instruments, and the LECO PEGASUS® 4D is the crown jewel of our science park. The results of GC-MS profiling performed using GC×GC technologies has madea strong impression on users and has seriously improved the quality of ourpublications. The fast-scanning capabilities of the TOF-analyzer effectively augment the dataobtained on the ordinary quadrupole, especially when working with the most complexmatrices which are most often the subject of metabolomics analysis. The reliability of the device is especially deserving of praise. The equipment can withstand a very demanding load with constant, round-the-clock operation."
"With the Pegasus BT 4D performing untargeted analysis today is very easy, thanks to the high sensitivity of the instrument, we are able to mine and analyze any type of sample! A combination of very good sensitivity, quality to price ratio and high flexibility make the Pegasus BT 4D system perfect for analysis of every sample"
University of Naples, Italy
"Pegasus BT is the perfect choice for identifying well-known metabolites at low concentration level in our sample, and also discovering new compounds. The most surprising advantage of the BT system is the ion source robustness! We usually work with dirty and complex samples, but we have never observed drop of sensitivity during our analyses.This reduces the time and cost of our analyses!"
"We use the LECO Pegasus BT instrument for the quantiﬁcation of small polar metabolites. We developed a hybrid method where we quantitate 51 metabolites with standard curves and screen for any other small polar metabolites in a wide range of biological samples. This assay has a great dynamic range thanks to the sensitivity of the BT. The StayClean® ion source allows us to run hundreds of samples in a batch and be conﬁ dent that the ion source will remain clean even with dirty samples such as plasma."
"Compared to GC equipped with a single column, the Pegasus 4D enabled me to separate unbelievable number of analytes! Tens of thousands of separated peaks in one run was not an exception. But where the separation was not perfect, ChromaTOF software and its deconvolution algorithm did the job. Such excellent ‘separating power’ helped me discover new types of plant PCB metabolites."
"This combination of ultrahigh chromatographic separation with high mass resolution might be still unique for a commercial available end user system."
Our new eBook summarises a large part of LECO’s application work in the field of food testing. In addition to the Application Compendium, the eBook includes an introduction to GC×GC- and TOFMS-technology, followed by an overview of the different hardware and software solutions that were used for the food testing applications. A bibliography with additional references can be found in the appendix.
The eBook is downloadable at SeparationScience now.
Download the eBook here…
We can now present our instruments and application solutions to you ONLINE, enabling you to gain insight into how LECO products could enhance your laboratory processes and results!
Visit us conveniently from your desk and without the need to travel. Our new ONLINE DEMO SERVICE allows you see product introductions and receive tips and tricks from our experts.
Would you like to know how we can help your sample analyses?
Just let us know and we can arrange a demo!
Contact your local sales team for an individual online appointment.
As laws and regulations change, cannabis and all it’s related chemical compounds of interest are showing up in a wide variety of consumer products. LECO instruments, that combine powerful Time-of-Flight Mass Spectrometry (TOF-MS) and Comprehensive Two Dimensional Gas Chromatography (GC×GC) technologies, can make your analyses more efficient. Find out here, how to save time and money by quantifying and identifying both the terpene and cannabinoids in just one injection. The same injection can even reveal the presence of pesticides and more!
How can we do this? Using GC×GC drastically increases analyte separation, which together with high quality full mass range spectra obtained by TOF-MS, enables powerful deconvolution analyte finding using ChromaTOF.
Do you want to learn more about "Determining Terpene Profiles of Cannabis Strains", then watch the presentation of Joe Binkley, Director - Separation Science Applications.
At LECO’S GC×GC Workshop & Symposium, Dr. Diane Turner gave a talk about "Selectivity: Wann, wo und wie man sie nutzt“ The talk covers techniques for sample analysis, selectivity in choosing the right technical setup (column choice, inlet parameters etc.), and also data analysis optimisation.
Meeting of the London Metabolomics Network and South East Region Analytical Division of the Royal Society of Chemistry at Burlington House, London
Alan Griffiths speaks about the top of the range technique for GC×GC Separation provided by LECO. The video has been recorded at the meeting of the London Metabolomics Network and South East Region Analytical Division of the Royal Society of Chemistry at Burlington House, London. The video will be uploaded to SepScience.com for our recent PEGASUS® campaign.
Fireworks are a staple of America’s Independence Day celebrations. It is estimated that 16,000 fireworks displays are held in the United States each year and American consumers will spend more than $1 billion in firework sales to mark the holiday! Beyond a big bang and bright lights, how do these fireworks affect the environmental world around them? LECO’s world headquarters are located in Saint Joseph, Michigan, a beach town on Lake Michigan where fireworks are a prominent backdrop to the 4th of July celebration. Last summer, our applications lab thought it would be a worthwhile and interesting experiment to test the water surrounding the firework launch spot to explore if there were any short-term environmental impacts. The influx of tourists to the Lake Michigan beaches during the holiday is sure to contribute chemicals from personal care products (sunscreen and insect repellent) to the water as well. Evaluating these potential contaminants surrounding the July 4th holiday was the objective of this study.
The analysis was conducted by taking water samples from three different places along the shoreline; the fireworks launch location off the pier, as well as two local beaches close to the launch site. This was done on July 2nd as well as on July 4th (an hour after the fireworks show) to provide an accurate measurement. LECO’s Pegasus HRT+ 4D system was used to analyse the water samples, which offers comprehensive two-dimensional gas chromatography coupled to high-resolution time-of-flight mass spectrometry (GC×GC-HRTOFMS). GC×GC-HRTOFMS proved a powerful tool for exploration as it provided a full non-targeted analysis of the water samples before and after the fireworks show, clearly demonstrating the chemical differences between the two. GC×GC-HRTOFMS was also able to pinpoint contributions to the environmental pollution that occurred as a result of these pyrotechnic displays and the increased human traffic near the water sampling sites.
So what happened to the water quality of Lake Michigan from the increased tourism and fireworks? The results may surprise you…
Non-targeted analysis, data science and innovation have synchronised to underpin the next generation of separation science analysis in mass spectrometry. LECO UK’s separations science product specialist Alan Griffiths explains.
“Ideas often spark one another, and chain reactions occur. As with chemical reactions, ideas can remain contained in relatively small areas before gradually spreading outward. California’s Silicon Valley is a focal point for technology. For mass spectrometry (MS), the UK’s city of Manchester is a focal point. Manchester is where the first commercial mass spectrometer built outside of the US was produced…“
Chemistry World // Issue 12/2019 // Article by Alan Griffiths
Ralf Löscher speaks about the latest technologies, as well as many years experience LECO has in the field of TOFMS instrumentation. The special focus of this interview refers to the food industry and the special benefits LECO offers to this market.
“In the field of chromatographic separation science technology, LECO offers GC coupled to time-of-flight (TOF) mass spectrometry (MS). This includes one-dimensional as well as two-dimensional chromatography (GC×GC), which increases chromatographic resolution and sensitivity. In addition, our latest technology is competitively priced in relation to triple quadrupole alternatives. Furthermore, GC-TOF-MS technology is basically unbeatable for the analysis of residues in complex matrices such as teas, spices, oily products, but also baby food.“
eFoodLab // Issue 02/2019 // Interview with Ralf Löscher
Congratulations to the winner of LECO UK’s first poster competition Rachel Hand of De Montfort University / The Open University and also to our runner-up Sonia García Alcega of The Open University.
Frank Dorman, an Associate Professor of Biochemistry and Molecular Biology at Penn State University, spoke at our ASMS breakfast seminar about his experience using our Pegasus BT 4D benchtop GC×GC-TOFMS to analyze environmental contamination in the Susquehanna river.
LECO’s PEGASUS® GC-HRT+ 4D will be the newest addition to the University of Southampton’s School of Chemistry, offering unique capabilities to UK researchers. Read what Professor John Langley has to say about the new mass spectrometer. “Highly advanced Southampton spectrometer to spearhead chemical research across southern region. Researchers across the south of England will analyse novel and strategically important chemistries through a new mass spectrometer at the University of Southampton.“
Interesting talks, excellent speakers, great conversations and discussions, stunning food and an amazing venue all lead to a great LS3UK in Manchester on 29 – 30 October.
LECO invites you to a diverse Metabolomics Analysis event at the EATC in Berlin. Expert speakers will present how the use of LECO GC-TOF-MS and GC×GC-TOF-MS enhances their latest target and untargeted metabolomics analysis applications in various fields such as Human disease, foodomics and plant biomarkers. These lectures will be supplemented with a laboratory session showcasing the latest LECO instrumentation and software. The participation is free of charge, including a special evening event on 27th November!